Nepurrtiti is one of the McBride family's two pet cats.
In "Baby Steps", Howard and Harold decide to adopt Nepurrtiti. Clyde mistakes their conversations for plans to have another baby rather than another kitten, so he gets Lincoln to help him learn big brother skills. When Howard and Harold reveal that they were actually preparing for a kitten and give Nepurrtiti to Clyde, he is initially disappointed that he is not getting a sibling, but soon comes to love his new kitten. The dads let Clyde watch over her for the night with his new brother skills.
In "Cheater by the Dozen", Lisa tries to install a surveillance system at the McBrides' house. When she sees Nepurrtiti's shadow, she thinks that it is a vicious beast, and runs away before Nepurrtiti shows herself and meows.
Nepurrtiti has lavender fur, large eyes, six whiskers, a white muzzle, and triangular ears.