Cleopawtra is the pet cat of the McBride family. In "April Fools Rules", she is extremely violent and vicious. Despite this, Clyde views her as a sibling, and seems to care a lot about her. Clyde, Howard, and Harold usually have to put Cleopawtra in a time-out crate when she gets feisty. However, in "Baby Steps" she is shown to be much calmer and docile.
In the episode "Baby Steps", the McBrides get a new kitten named Nepurrtiti, who is supposed to be Cleopawtra's sister from a different litter of kittens.
Cleopawtra has orange fur, razor-sharp claws, jagged teeth, and bright green eyes. Her crate is red and silver.